Schiff base functionalized silica gel for simultaneous separation and preconcentration of Cu(II), Ni(II), and Cd(II) in pharmaceuticals and water samples

A method for separation and preconcentration of Cu(II), Ni(II), Cd(II) using N-N'-bis(5-methoxsalicylidene)-2-hydroxy-1,3-propanediamine modified silica gel was improved aqueous samples pharmaceuticals. Determination the analytes achieved by inductively coupled plasma optic emission spectrometry. The experimental conditions including pH value, sample volume, eluent type sorbent mass, sample, flow rates were optimized with univariate multivariate optimization tools. relative standard deviations 2.9% 3.0% 3.3% recovery values between 98.8 ± 3.2-101.5 3.0%. limits detection found to be 62.4, 39.5, 28.2 ng L-1 Cd(II), respectively. accuracy suggested procedure tested certified reference material (Certipur ICP multi-element solution IV) addition-recovery experiments. successfully applied eye drop, anesthetic, serum, tap water, mineral spring water samples.